Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610064, China.
Colloids Surf B Biointerfaces. 2011 Dec 1;88(2):749-54. doi: 10.1016/j.colsurfb.2011.08.015. Epub 2011 Aug 22.
A facile electrospinning method has been utilized to fabricate poly (N-isopropylacrylamide) (PNIPAM)/poly (ethylene oxide) (PEO) blend nanofibers having the mean fiber diameters from approximately 250 to 380 nm. Scanning electron microscopy (SEM) images showed that the morphology and diameter distribution of the nanofibrous scaffolds can be easily modulated by changing the weight ratio of PNIPAM/PEO in electrospinning solution. X-ray diffraction (XRD) and thermogravimetric analysis (TGA) demonstrated that there were interactions between the molecules of PNIPAM and PEO. Vitamin B12 was chosen as a hydrophilic model drug for in situ encapsulation in PNIPAM/PEO blend nanofibrous scaffolds. The rate of drug release can be controlled by adjusting the weight ratio of PNIPAM/PEO, the temperature of release medium and the drug loading amount. It is suggested that the blend nanofibrous scaffold could be used as a new thermo-responsive matrix for the entrapment and controlled release of drugs.
一种简单的静电纺丝方法被用来制备具有平均纤维直径约 250 至 380nm 的聚（N-异丙基丙烯酰胺）（PNIPAM）/聚（氧化乙烯）（PEO）共混纳米纤维。扫描电子显微镜（SEM）图像表明，通过改变静电纺丝溶液中 PNIPAM/PEO 的重量比，可以很容易地调节纳米纤维支架的形态和直径分布。X 射线衍射（XRD）和热重分析（TGA）表明，PNIPAM 和 PEO 分子之间存在相互作用。维生素 B12 被选为亲水性模型药物，用于原位包封在 PNIPAM/PEO 共混纳米纤维支架中。通过调整 PNIPAM/PEO 的重量比、释放介质的温度和药物负载量，可以控制药物的释放速率。研究表明，共混纳米纤维支架可用作包埋和控制药物释放的新型热敏基质。
