Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 26/28 Krakowskie Przedmieście Street, 00-927 Warsaw, Poland.
Behav Brain Res. 2011 Dec 1;225(2):655-9. doi: 10.1016/j.bbr.2011.08.029. Epub 2011 Aug 27.
The role of the GABA-A alpha-2 receptor subunit in the basolateral amygdala (BLA), dentate gyrus of the hippocampus (DG) and prefrontal cortex (M2 area) during a fear session (performed one week after the conditioned fear test), was studied. We employed a model of high (HR) and low anxiety (LR) rats divided according to their conditioned freezing response. Pretreatment of rats with d-cycloserine immediately before the fear session attenuated fear response in HR and LR rats and increased the density of alpha-2 subunits in the BLA, M2 area and DG of HR animals. The less potent behavioural influence of midazolam (in HR group only) was linked to the increased expression of alpha-2 subunit in M2 area and DG. These results support a role of the GABA-A receptor alpha-2 subunit in processing of emotional cortico-hippocampal input to the BLA.
在恐惧阶段（在条件性恐惧测试后一周进行），研究了 GABA-A 阿尔法-2 受体亚基在基底外侧杏仁核（BLA）、海马齿状回（DG）和前额皮质（M2 区）中的作用。我们采用了根据条件性冻结反应划分的高焦虑（HR）和低焦虑（LR）大鼠模型。在恐惧阶段之前立即用 d-环丝氨酸预处理大鼠，可减轻 HR 和 LR 大鼠的恐惧反应，并增加 HR 动物 BLA、M2 区和 DG 中的 alpha-2 亚基密度。咪达唑仑（仅在 HR 组中）的行为影响较弱，与 M2 区和 DG 中 alpha-2 亚基表达增加有关。这些结果支持 GABA-A 受体 alpha-2 亚基在处理情绪皮质-海马传入到 BLA 中的作用。
