比利时人体无形体病的 10 年血清流行病学研究。

Human anaplasmosis in Belgium: a 10-year seroepidemiological study.

机构信息

Research Laboratory and Reference Laboratory for Vector-borne Diseases, Queen Astrid Military Hospital, B-1120 Brussels, Belgium.

出版信息

Ticks Tick Borne Dis. 2011 Sep;2(3):156-9. doi: 10.1016/j.ttbdis.2011.06.004. Epub 2011 Aug 25.

DOI:10.1016/j.ttbdis.2011.06.004

PMID:21890069

Abstract

Human granulocytic anaplasmosis (HGA) is a tick-borne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. Although the pathogen was known as a veterinary agent as early as 1932, the link with human disease was first established in 1990. In the past decennium, the involvement of HGA as an important and frequent cause of fever with a history of tick bite was increasingly recognized in many regions of Europe. This paper presents a 10-year A. phagocytophilum serosurveillance (2000-2009), wherein 1672 serum samples were tested and 418 were found positive. A total of 111 patients had a history of tick bite, fever, and at least a 4-fold rise in titre and are thus considered to be confirmed cases. These findings suggest that Belgium is a hot spot for HGA infections.

摘要

人粒细胞无形体病（HGA）是一种由嗜吞噬细胞无形体引起的中性粒细胞蜱传立克次体感染。尽管早在 1932 年，该病原体就已被认为是一种兽医病原体，但它与人类疾病的联系最早是在 1990 年建立的。在过去的十年中，HGA 作为一种重要且常见的蜱咬史发热病因，在欧洲的许多地区越来越受到关注。本文介绍了一项为期 10 年的嗜吞噬细胞无形体血清监测（2000-2009 年），共检测了 1672 份血清样本，发现 418 份呈阳性。共有 111 例患者有蜱咬史、发热和至少 4 倍的滴度升高，因此被认为是确诊病例。这些发现表明，比利时是 HGA 感染的热点地区。