University of Toledo Medical Center, Toledo, Ohio, USA.
Fertil Steril. 2011 Nov;96(5):1145-8. doi: 10.1016/j.fertnstert.2011.08.009. Epub 2011 Sep 3.
To identify early ultrasound markers in pregnant patients that predict a favorable pregnancy outcome.
Retrospective case-control study.
Infertility patients in fertility clinic.
PATIENT(S): 1051 women with early pregnancies conceived after fertility treatment.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Ongoing pregnancy >20 weeks' gestation.
RESULT(S): Ongoing pregnancy rate was 90.5% for those pregnancies having early fetal cardiac activity (odds ratio [OR] = 66.5). Gestational sac diameter ≥12 mm was associated with ongoing pregnancy rate of 91.9%. Small gestational sac diameter, <8 mm, was associated with high miscarriage rate, 85.3%. Ongoing pregnancy rates for yolk sac diameter <2 mm, 2-6 mm, and >6 mm were 20%, 89.2%, and 20%, respectively (OR = 33.1, 2-6 vs <2 mm; OR = 33.1, 2-6 vs >6 mm). Ongoing pregnancy rate was 94% when all three markers were present.
CONCLUSION(S): On postconception days 33-36, gestational sac diameter ≥12 mm, yolk sac diameter 2-6 mm, and the presence of fetal cardiac activity were favorable markers.
确定预测妊娠结局良好的孕妇早期超声标志物。
回顾性病例对照研究。
生育诊所的不孕患者。
1051 名接受生育治疗后怀孕的早期妊娠患者。
无。
妊娠 20 周以上的持续妊娠。
有早期胎儿心脏活动的妊娠持续妊娠率为 90.5%（优势比[OR] = 66.5）。妊娠囊直径≥12mm与持续妊娠率为 91.9%相关。妊娠囊直径小，<8mm，与高流产率（85.3%）相关。卵黄囊直径<2mm、2-6mm 和>6mm 的持续妊娠率分别为 20%、89.2%和 20%（OR=33.1，2-6 vs <2mm；OR=33.1，2-6 vs >6mm）。当所有三个标志物均存在时，持续妊娠率为 94%。
在受孕后第 33-36 天，妊娠囊直径≥12mm、卵黄囊直径 2-6mm 以及胎儿心脏活动存在是有利的标志物。
