INSERM U836, EFSN, Psychiatry and Neurology Pole, Grenoble Institut of Neurosciences, CHU Grenoble, Grenoble cedex 9, France.
Rev Neurol (Paris). 2011 Oct;167(10):751-61. doi: 10.1016/j.neurol.2011.08.007. Epub 2011 Sep 3.
Epilepsy associated with brain tumors presents with specific features deserving medical attention. Although commonly reported in patients with brain tumor, either as revealing mode or as a remote complication, limited knowledge is available regarding their epidemiology, clinical evolution, surgical outcome, physiopathology and treatment, providing only clues for clinical management. Seizures appear even more threatening for patients and caregivers, providing seizures could mean tumor progression and recurrence. This factor adds to the negative impact of epilepsy carried on quality of life measures. Pharmacotherapy is complicated by the use of chemotherapy and interaction between antiepileptic drugs and antineoplastic agents are frequent and potentially harmful. The high incidence of epilepsy enlights the question of prophylaxy with antiepileptic drugs, in patients without seizures, or during the perioperative period, and after surgery, when gross total resection has been achieved. This article attempts to provide the reader with an overview of brain tumor epilepsy in its specific aspects and to comment on some remaining issues.
与脑瘤相关的癫痫具有值得关注的特定特征。尽管在脑瘤患者中常被报道，无论是作为揭示模式还是作为远程并发症，但对于其流行病学、临床演变、手术结果、病理生理学和治疗，我们的了解有限，仅为临床管理提供线索。癫痫发作对患者和护理人员来说更为威胁，因为癫痫发作可能意味着肿瘤进展和复发。这一因素增加了癫痫对生活质量衡量的负面影响。化疗的使用使药物治疗复杂化，抗癫痫药物与抗肿瘤药物之间的相互作用很常见且具有潜在危害。癫痫的高发病率凸显了预防性使用抗癫痫药物的问题，无论是在无癫痫发作的患者中，还是在围手术期，以及在实现大体全切除术后。本文试图为读者提供关于脑瘤癫痫的概述，并对一些遗留问题进行评论。
