Bovine enterovirus CPE at different multiplicities of infection in the absence of viral RNA synthesis.

When bovine enterovirus (BEV) RNA synthesis was inhibited by 2-(alpha-hydroxybenzyl)-benzimidazole (HBB), an increase in MOI was accompanied by an enhancement of cytopathology. Since BEV RNA synthesis is inhibited and BEV protein synthesis is allowed to proceed in the presence of HBB, these results support the concept that proteins play a role in the development of cytopathology independently of viral double-stranded RNA.