Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat, India.
Bioorg Med Chem Lett. 2011 Oct 15;21(20):6166-9. doi: 10.1016/j.bmcl.2011.07.123. Epub 2011 Aug 6.
A new series of fused pyran derivatives 5a-x bearing 2-morpholinoquinoline nucleus has been synthesized under microwave irradiation by a reaction of 2-morpholinoquinoline-3-carbaldehyde 2a-c, malononitrile 3 and compounds 4a-h in presence of NaOH as basic catalyst. All the compounds were screened against three Gram positive bacteria (Streptococcus pneumoniae, Clostridium tetani, Bacillus subtilis), three Gram negative bacteria (Salmonella typhi, Vibrio cholerae, Escherichia coli) and two fungi (Aspergillus fumigatus, Candida albicans) using broth microdilution MIC (Minimum Inhibitory Concentration) method. Of the compounds studied, compounds 5b, 5f, 5k, 5m, 5q, 5s and 5v have found to be most efficient members of the series.
一个新的系列的融合吡喃衍生物 5a-x 轴承 2-吗啉基喹啉核已经合成了微波辐射下的反应 2-吗啉基喹啉-3-醛 2a-c, 丙二腈 3 和化合物 4a-h 在 NaOH 存在的基本催化剂。所有的化合物都被筛选了三个革兰氏阳性菌(肺炎链球菌、破伤风梭菌、枯草芽孢杆菌),三个革兰氏阴性菌(伤寒沙门氏菌、霍乱弧菌、大肠杆菌)和两个真菌(烟曲霉、白色念珠菌)使用肉汤微量稀释 MIC (最低抑菌浓度)的方法。的化合物研究,化合物 5b、5f、5k、5m、5q、5s 和 5v 已被发现是最有效的成员的系列。
