Department of Otorhinolaryngology and Head and Neck Surgery, Izzet Baysal Medicine Faculty of Abant Izzet Baysal University, Bolu, Turkey.
J Photochem Photobiol B. 2011 Oct 5;105(1):94-7. doi: 10.1016/j.jphotobiol.2011.07.006. Epub 2011 Aug 18.
Allergic rhinitis is a high-incidence allergic inflammation of the nasal airways that impacts quality of life. Of the numerous therapies used to treat allergic rhinitis, intranasal phototherapy has emerged as a promising new treatment modality for inflammatory airway disease. Phototherapy is widely used for the treatment of immune-mediated skin diseases because its profound immunosuppressive effect inhibits hypersensitivity reactions in the skin. Intranasal phototherapy using a combination of Ultraviolet-A (UVA) and Ultraviolet-B (UVB) plus Visible light (VIS) has been shown to suppress the clinical symptoms of allergic rhinitis, but limited data regarding its adverse effects on the nasal mucosa currently exists. In this study, we demonstrate that UV displays no harmful effects on the nasal mucosa cells of rabbits following 2 weeks of intranasal phototherapy.
变应性鼻炎是一种高发的鼻气道过敏炎症，会影响生活质量。在众多用于治疗变应性鼻炎的疗法中，鼻内光疗已成为一种有前途的治疗气道炎症性疾病的新方法。光疗因其强大的免疫抑制作用可抑制皮肤的超敏反应，因此被广泛用于治疗免疫介导的皮肤病。联合使用长波紫外线（UVA）、中波紫外线（UVB）和可见光（VIS）的鼻内光疗已被证实可抑制变应性鼻炎的临床症状，但目前关于其对鼻黏膜的不良反应的数据有限。在这项研究中，我们证明了在 2 周的鼻内光疗后，紫外线对兔的鼻黏膜细胞没有不良影响。
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