Koreck Andrea, Csoma Zsanett, Ignácz Ferenc, Bodai Lászó, Kadocsa Edit, Szabó Gábor, Bor Zsolt, Nékám Kristóf, Dobozy Attila, Kemény Lajos
Szegedi Tudományegyetem, Szent-Györgyi Albert Orvos- és Gyógyszerésztudományi Centrum, Altalános Orvostudományi Kar, Borgyógyászati és Allergológiai Klinika, Szeged.
Orv Hetil. 2005 May 8;146(19):965-9.
Allergic rhinitis is a frequent disease, accompanied by significant social-economic costs and a negative impact on the quality of life. Phototherapy has a profound immunosuppressive effect and is effectively used in the treatment of several immune mediated skin diseases such as atopic dermatitis.
The authors investigated the efficacy of intranasal phototherapy with a combination of low doses of ultraviolet-B, ultraviolet-A and visible light in allergic rhinitis.
A randomized, double-blind, placebo-controlled study was conducted in patients with a history of at least 2 years of moderate to severe ragweed-induced allergic rhinitis that was not controlled by anti-allergic drugs. Intranasal phototherapy was performed 3 times a week for 3 weeks. As placebo low intensity visible light was used.
Phototherapy resulted in a significant improvement of clinical symptoms for nasal itching, rhinorrhea, sneezing and total nasal score. Scores for nasal obstruction slightly improved during phototherapy while a significant increased was found in the placebo group. In the overall efficacy assessment, both patients and investigators found phototherapy significantly more efficient than placebo. Phototherapy was well tolerated, the only side effect was the slight dryness of the nasal mucosa.
These results suggest that intranasal phototherapy is effective for the treatment of allergic rhinitis, and opens up new opportunities for the treatment of immune-mediated mucosal diseases.
过敏性鼻炎是一种常见疾病，伴随着巨大的社会经济成本，并对生活质量产生负面影响。光疗具有显著的免疫抑制作用，已有效应用于多种免疫介导的皮肤病，如特应性皮炎的治疗。
作者研究低剂量紫外线B、紫外线A和可见光联合鼻腔光疗对过敏性鼻炎的疗效。
对有至少2年中重度豚草诱发的过敏性鼻炎病史且抗过敏药物治疗无效的患者进行一项随机、双盲、安慰剂对照研究。鼻腔光疗每周进行3次，共3周。使用低强度可见光作为安慰剂。
光疗使鼻痒、流涕、打喷嚏和总鼻症状评分等临床症状显著改善。光疗期间鼻塞评分略有改善，而安慰剂组则显著增加。在总体疗效评估中，患者和研究者均发现光疗比安慰剂显著更有效。光疗耐受性良好，唯一的副作用是鼻粘膜轻微干燥。
这些结果表明鼻腔光疗对过敏性鼻炎治疗有效，并为免疫介导的粘膜疾病治疗开辟了新机会。
