Carpenter S, Karpati G, Zubrzycka-Gaarn E, Bulman D E, Ray P N, Worton R G
Neuromuscular Research Group, Montreal Neurological Institute, Quebec, Canada.
Muscle Nerve. 1990 May;13(5):376-80. doi: 10.1002/mus.880130503.
Electron-microscopic immunoperoxidase technique revealed plasmalemmal localization of dystrophin in microscopically normal human skeletal muscle fibers obtained from nine routine diagnostic muscle biopsies. There was no evidence of periodicity of the immunoreactive product nor was there any evidence of immunostaining in any organelle besides the plasma membrane. Dystrophin appears to be a cytoskeletal protein associated with the plasmalemma. Its function is presumed to be the maintenance of the mechanical stability of the surface membrane so that it can withstand the normal contraction-induced stresses without disruption.
电子显微镜免疫过氧化物酶技术显示，从9例常规诊断性肌肉活检获取的微观结构正常的人类骨骼肌纤维中，肌营养不良蛋白定位于质膜。没有证据表明免疫反应产物具有周期性，除质膜外，在任何细胞器中也没有免疫染色的证据。肌营养不良蛋白似乎是一种与质膜相关的细胞骨架蛋白。据推测，其功能是维持表面膜的机械稳定性，使其能够承受正常收缩引起的应力而不被破坏。
