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大剂量口服氟康唑治疗巴西利什曼原虫引起的皮肤利什曼病有效。

High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis.

机构信息

Department of Internal Medicine, School of Medicine, Federal University of Ceará,Fortaleza, Ceará, Brazil.

出版信息

Clin Infect Dis. 2011 Oct;53(7):693-5. doi: 10.1093/cid/cir496.

DOI:10.1093/cid/cir496
PMID:21890773
Abstract

We report for the first time the successful use of fluconazole to treat cutaneous leishmaniasis due to Leishmania braziliensis. We used escalating doses from 5 to 8 mg/kg per day. At a dose of 5 mg/kg per day, 75% patients were cured, and at 8 mg/kg per day, the cure rate was 100%. Fluconazole was well tolerated.

摘要

我们首次报告了氟康唑成功治疗巴西利什曼原虫引起的皮肤利什曼病。我们使用了 5 至 8 毫克/公斤/天的递增剂量。每天 5 毫克/公斤的剂量，75%的患者治愈，每天 8 毫克/公斤的剂量，治愈率为 100%。氟康唑耐受性良好。

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引用本文的文献

[1]
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BMC Infect Dis. 2024-3-20

[2]
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PLoS One. 2023

[3]
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PLoS One. 2023

[4]
Therapy of cutaneous leishmaniasis caused by Leishmania braziliensis with fluconazole.

Dermatol Ther. 2021-9

[5]
Interventions for American cutaneous and mucocutaneous leishmaniasis.

Cochrane Database Syst Rev. 2020-8-27

[6]
Failure of Liposomal-amphotericin B Treatment for New World Cutaneous Leishmaniasis due to Leishmania braziliensis.

Intern Med. 2020

[7]
Susceptibility testing of Leishmania spp. against amphotericin B and fluconazole using the Sensititre™ YeastOne™ YO9 platform.

BMC Infect Dis. 2019-7-8

[8]
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Parasitology. 2018-12

[9]
Failure of fluconazole in treating cutaneous leishmaniasis caused by Leishmania guyanensis in the Brazilian Amazon: An open, nonrandomized phase 2 trial.

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[10]
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