七氟醚麻醉预处理对猪实验性自体肺移植模型的影响。
The effects of anesthetic preconditioning with sevoflurane in an experimental lung autotransplant model in pigs.
机构信息
Department of Anesthesiology, Gregorio Maranon University General Hospital, c/querol 5,3°c, Madrid, 28033, Spain.
出版信息
Anesth Analg. 2011 Oct;113(4):742-8. doi: 10.1213/ANE.0b013e3182288e01. Epub 2011 Sep 2.
BACKGROUND
Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs.
METHODS
Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points.
RESULTS
There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups.
CONCLUSIONS
We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model.
背景
由于与 1 侧肺相关的通气损伤，缺血再灌注肺损伤在胸外科中尤为重要。在这项研究中，我们评估了七氟醚在猪肺自体移植模型中的细胞保护作用。
方法
20 头大白猪接受肺切除术加肺自体移植，根据接受的麻醉（异丙酚或七氟醚）分为 2 个 10 人组。在 5 个不同的时间点测量促炎介质、氧化应激、一氧化氮代谢以及血液动力学和血液变量。
结果
在异丙酚组中，氧化应激标志物和促炎介质增加，而两组的血液动力学变量相似。
结论
我们证明了七氟醚可降低活体缺血再灌注肺模型中的炎症反应和氧化应激。
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