He Y, Campbell T C
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.
Nutr Cancer. 1990;13(4):243-53. doi: 10.1080/01635589009514066.
The effects of beta-carotene, canthaxanthin, and extracts of tomato paste (containing lycopene) and orange juice (containing cryptoxanthin) on aflatoxin B1 (AFB1)-induced mutagenesis in S. typhimurium TA 100 and TA 98 were investigated. Inhibition of mutagenesis was studied during and following completion of AFB1 metabolism (i.e., after the addition of menadione), thereby permitting separate examination of the metabolic activation and phenotypic expression phases. Each experimental carotenoid, except lycopene, inhibited AFB1-induced mutagenesis in both tester strains. Cryptoxanthin was the most potent inhibitor, being at least an order of magnitude more potent than the other carotenoids. Inhibition by beta-carotene and canthaxanthin was more prominent during the activation phase, whereas cryptoxanthin was more effective during the subsequent phenotypic expression phase. These inhibitory effects were not dependent on conversion to retinol.
研究了β-胡萝卜素、角黄素、番茄酱提取物（含番茄红素）和橙汁提取物（含隐黄质）对鼠伤寒沙门氏菌TA 100和TA 98中黄曲霉毒素B1（AFB1）诱导的诱变作用。在AFB1代谢过程中及代谢完成后（即加入甲萘醌后）研究了诱变抑制情况，从而可以分别检查代谢活化和表型表达阶段。除番茄红素外，每种实验类胡萝卜素均抑制两种测试菌株中AFB1诱导的诱变。隐黄质是最有效的抑制剂，其效力至少比其他类胡萝卜素高一个数量级。β-胡萝卜素和角黄素的抑制作用在活化阶段更为突出，而隐黄质在随后的表型表达阶段更有效。这些抑制作用不依赖于向视黄醇的转化。
