Meier P
Department of Statistics, University of Chicago, IL 60637.
Stat Med. 1990 Jan-Feb;9(1-2):13-6. doi: 10.1002/sim.4780090107.
The Salk Vaccine Field Trial was a randomized, placebo-controlled trial designed to test the efficacy of the Salk killed virus vaccine. Although the trial was not without some problems, both in design and analysis, none was important enough to raise serious questions about the results. Thus, the design of the Field Trial was well adapted to the demanding requirements. The trial owes its success in a large part to substantial public involvement. In designing future, large-scale, simple trials, we may still be able to benefit from the lessons of the Polio Vaccine Trial.
索尔克疫苗现场试验是一项随机、安慰剂对照试验，旨在测试索尔克灭活病毒疫苗的疗效。尽管该试验在设计和分析方面都存在一些问题，但没有一个问题严重到足以对结果提出严重质疑。因此，现场试验的设计很好地适应了严格的要求。该试验的成功在很大程度上归功于公众的大量参与。在设计未来大规模、简单的试验时，我们或许仍能从脊髓灰质炎疫苗试验的经验教训中受益。
