Udagawa Masaru, Dai Yuichi, Gen Toukichi, Nakao Keisuke, Shimoshiro Reina, Okamoto Hiroyuki, Inadome Yukinori, Morishita Yukio, Osamura Yoshiyuki
Department of Surgery, JA Toride Medical Center.
Nihon Shokakibyo Gakkai Zasshi. 2011 Sep;108(9):1554-65.
We report 2 cases of ileocecal carcinoid with review of the literature recently reported in Japan. Both cases were diagnosed as carcinoid by colonoscopic biopsy after ileocecal tumors had been pointed out by computed tomography. We performed curative operation with lymph node dissection. Since multiple lymph node metastases were shown in both cases pathologically, they were closely followed after surgery, but no recurrence has been shown. Since SSTR2a stain was strongly positive in both cases, octreotide, the effectiveness of which was verified in the PROMID study might be administered if necessary. As ileocecal carcinoid has a tendency to metastasize to other organs, careful surveillance by colonoscopy and early detection are required. Furthermore, development of effective drugs following octreotide and further investigation including biological and histopathological analysis of neuroendocrine tumors including carcinoid are necessary.
我们报告2例回盲部类癌，并回顾了日本近期报道的文献。这2例病例在计算机断层扫描发现回盲部肿瘤后，经结肠镜活检确诊为类癌。我们进行了根治性手术并清扫淋巴结。病理检查显示这2例病例均有多发淋巴结转移，术后对其进行了密切随访，但均未出现复发。由于这2例病例的SSTR2a染色均呈强阳性，如有必要，可能会给予奥曲肽，其有效性已在PROMID研究中得到证实。由于回盲部类癌有向其他器官转移的倾向，因此需要通过结肠镜进行仔细监测并早期发现。此外，开发继奥曲肽之后的有效药物以及对包括类癌在内的神经内分泌肿瘤进行包括生物学和组织病理学分析在内的进一步研究是必要的。
