Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Tohoku J Exp Med. 2011 Oct;225(2):81-4. doi: 10.1620/tjem.225.81.
The genus Aeromonas comprises flagellated gram-negative rods widely distributed in freshwater, estuarine and marine environments. Aeromonas species may cause a variety of illnesses in humans, such as enterocolitis and septicemia, especially in warmer tropical or subtropical environments. To recognize the characteristics of Aeromonas septicemia in Japan, we reviewed laboratory data and medical records in our hospital. During 11 years (from 2000 to 2010), Aeromonas septicemia was observed in seven patients involving six female subjects. Six patients were observed in summer or fall. The incidence of Aeromonas septicemia was about 0.07 per 1000 admissions, and two out of the seven patients died. All patients had underlying diseases such as malignancy (six patients) and choledocholithiasis (one patient). Two patients developed septicemia within two days after ingesting raw seafood. Five patients developed Aeromonas septicemia > 48 h after admission. Fever was present in all patients, and four out of the seven patients developed septic shock. All patients developed monomicrobial septicemia. A. hydrophila was isolated from five patients, and A. caviae and A. veronii biovar sobria were isolated from one patient each. Most antimicrobial agents had high activity against the isolated strains. However, a carbapenem-resistant strain appeared in one patient during treatment and led to death. Aeromonas septicemia is uncommon in temperate areas but can occur particularly in warm seasons. Immunocompromised conditions and recent ingestion of raw fish or shellfish are important characteristics of developing Aeromonas septicemia.
气单胞菌属包含有鞭毛的革兰氏阴性杆菌，广泛分布于淡水、河口和海洋环境中。气单胞菌可引起人类多种疾病，如肠炎和败血症，尤其是在温暖的热带或亚热带环境中。为了了解日本气单胞菌败血症的特征，我们回顾了我院的实验室数据和病历。在 11 年（2000 年至 2010 年）期间，有 7 例气单胞菌败血症患者，涉及 6 名女性。6 例患者发生在夏季或秋季。气单胞菌败血症的发病率约为每 1000 例入院 0.07 例，7 例患者中有 2 例死亡。所有患者均有基础疾病，如恶性肿瘤（6 例）和胆总管结石（1 例）。2 例患者在食用生海鲜后 2 天内发生败血症。5 例患者在入院后>48 小时发生气单胞菌败血症。所有患者均有发热，7 例患者中有 4 例发生感染性休克。所有患者均发生单一微生物败血症。5 例患者分离出嗜水气单胞菌，1 例患者分别分离出豚鼠气单胞菌和温和气单胞菌亚种。大多数抗菌药物对分离株具有高活性。然而，在 1 例患者的治疗过程中出现了一种碳青霉烯类耐药株，导致死亡。气单胞菌败血症在温带地区不常见，但在温暖季节可能会发生。免疫功能低下和近期食用生鱼或贝类是发生气单胞菌败血症的重要特征。
