AMPK 信号通路协调细胞生长、自噬和代谢。
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
机构信息
Molecular & Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
出版信息
Nat Cell Biol. 2011 Sep 2;13(9):1016-23. doi: 10.1038/ncb2329.
Abstract
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
摘要
真核生物细胞和整体代谢的一个核心调节剂是 AMP 激活的蛋白激酶（AMPK），当细胞内 ATP 生成减少时，AMPK 被激活。AMPK 在调节生长和重编程代谢方面具有关键作用，并且最近与自噬和细胞极性等细胞过程相关。在这里，我们综述了 AMPK 功能的机制理解方面的一些最新突破，重点介绍了一些新发现的 AMPK 的下游效应物。
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2
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3
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4
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