Delli Florentina Silvia, Zaraboukas Thomas, Mandekou-Lefaki Ioanna
Dermatology Department, Private Practice, Thessaloniki, Greece.
Clin Med Oncol. 2008;2:153-8. Epub 2008 Mar 19.
Primary cutaneous lymphomas are the second most common site of extranodal non-Hodgkin lymphoma. A specifically type named extranodal marginal zone B-cell lymphomas are indolent low-grade neoplasma.We report a case of a 42-year-old white man with multiple subcutaneous tumors located on the trunk and neck. The histopathological exam showed a non-epidermotropic, dense lymphocytic infiltrate. Histologic, immunohistochemical and cytologenetic analysis diagnosed primary cutaneous B-cell lymphoma MALT type. Investigation for other extranodal MALT lymphoma gastrointestinal tract, lung, salivary and thyroid glands was negative. The patient refused radiotherapy, but he accepted every 6 months close follow-up. Over a seven years period, we noticed a progressively disappearance of the skin lesions.The necessity of aggressive treatment of this disease with excellent prognosis is discussed.The treatment necessity of primary cutaneous B-cell lymphoma MALT type is discussed.
原发性皮肤淋巴瘤是结外非霍奇金淋巴瘤的第二常见部位。一种特殊类型的结外边缘区B细胞淋巴瘤是惰性低度肿瘤。我们报告一例42岁白人男性，其躯干和颈部有多个皮下肿瘤。组织病理学检查显示为非亲表皮性致密淋巴细胞浸润。组织学、免疫组织化学和细胞遗传学分析诊断为原发性皮肤MALT型B细胞淋巴瘤。对胃肠道、肺、唾液腺和甲状腺等其他结外MALT淋巴瘤的检查为阴性。患者拒绝放疗，但接受每6个月的密切随访。在7年的时间里，我们注意到皮肤病变逐渐消失。讨论了对这种预后良好的疾病进行积极治疗的必要性。讨论了原发性皮肤MALT型B细胞淋巴瘤的治疗必要性。
