• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

恶性肿瘤中细胞凋亡的放射性核素成像：锝-海尼克-重组人膜联蛋白V成像的前景与局限

Radionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of Tc-Hynic-rh-Annexin V Imaging.

作者信息

Kartachova M S, Verheij M, van Eck B L, Hoefnagel C A, Olmos R A Valdes

机构信息

Department of Nuclear Medicine, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

出版信息

Clin Med Oncol. 2008;2:319-25. doi: 10.4137/cmo.s349. Epub 2008 Mar 25.

DOI:10.4137/cmo.s349
PMID:21892293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3161632/
Abstract

Radionuclide detection of apoptosis with of (99m)Tc-Hynic-rh-Annexin V scintigraphy is an effective tool for in vivo visualisation and monitoring of apoptosis in various malignant tumour. Early therapy-induced increase of the tumour tracer uptake correlates with favourable outcome, whereas stable or decreased uptake correlates with stable disease or tumour progression. Therefore sequential (99m)Tc-Hynic-rh-Annexin V scintigraphy could be used to predict therapy outcome on a patient-to-patient basis within 48 hours after the start of treatment. However, moderate tumour-to-background ratio and therapy-induced changes in normal tissues could confound image analysis. To assure accurate interpretation of Annexin V scans, the awareness of the biophysiological and biochemical properties contributing to the tracer distribution is essential. In with manuscript we discuss the patterns of Annexin V tumour uptake and illustrate the most frequent pitfalls associated with Annexin V imaging in correlation with CT and MRI imaging.

摘要

用（99m）Tc-Hynic-rh-膜联蛋白V闪烁显像进行放射性核素凋亡检测是体内可视化和监测各种恶性肿瘤细胞凋亡的有效工具。早期治疗引起的肿瘤示踪剂摄取增加与良好预后相关，而摄取稳定或降低则与疾病稳定或肿瘤进展相关。因此，序贯（99m）Tc-Hynic-rh-膜联蛋白V闪烁显像可用于在治疗开始后48小时内对患者个体的治疗结果进行预测。然而，中等的肿瘤与背景比值以及治疗引起的正常组织变化可能会混淆图像分析。为确保对膜联蛋白V扫描结果的准确解读，了解有助于示踪剂分布的生物物理和生化特性至关重要。在本手稿中，我们讨论了膜联蛋白V在肿瘤中的摄取模式，并说明了与CT和MRI成像相关的膜联蛋白V成像最常见的陷阱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/e7789a8f6a43/cmo-2-2008-319f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/600263449366/cmo-2-2008-319f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/5b5388f5ed73/cmo-2-2008-319f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/f2c4f674c203/cmo-2-2008-319f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/3dbc5a0a6fb6/cmo-2-2008-319f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/af33f9864246/cmo-2-2008-319f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/5db79c43123a/cmo-2-2008-319f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/cc339eb3ac78/cmo-2-2008-319f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/0e40af6c368d/cmo-2-2008-319f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/e7789a8f6a43/cmo-2-2008-319f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/600263449366/cmo-2-2008-319f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/5b5388f5ed73/cmo-2-2008-319f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/f2c4f674c203/cmo-2-2008-319f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/3dbc5a0a6fb6/cmo-2-2008-319f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/af33f9864246/cmo-2-2008-319f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/5db79c43123a/cmo-2-2008-319f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/cc339eb3ac78/cmo-2-2008-319f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/0e40af6c368d/cmo-2-2008-319f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2512/3161632/e7789a8f6a43/cmo-2-2008-319f9.jpg

相似文献

1
Radionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of Tc-Hynic-rh-Annexin V Imaging.恶性肿瘤中细胞凋亡的放射性核素成像：锝-海尼克-重组人膜联蛋白V成像的前景与局限
Clin Med Oncol. 2008;2:319-25. doi: 10.4137/cmo.s349. Epub 2008 Mar 25.
2
In vivo imaging of apoptosis by 99mTc-Annexin V scintigraphy: visual analysis in relation to treatment response.通过99mTc-膜联蛋白V闪烁扫描术对细胞凋亡进行体内成像：与治疗反应相关的视觉分析
Radiother Oncol. 2004 Sep;72(3):333-9. doi: 10.1016/j.radonc.2004.07.008.
3
Mapping of treatment-induced apoptosis in normal structures: 99mTc-Hynic-rh-annexin V SPECT and CT image fusion.正常结构中治疗诱导凋亡的映射：99mTc-Hynic-rh-膜联蛋白V单光子发射计算机断层显像与计算机断层扫描图像融合
Eur J Nucl Med Mol Imaging. 2006 Aug;33(8):893-9. doi: 10.1007/s00259-006-0070-1. Epub 2006 Apr 4.
4
Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis.锝-99m 联肼尼克酰胺-膜联蛋白V：一种用于体内检测细胞凋亡的潜在放射性药物。
Eur J Nucl Med. 1999 Oct;26(10):1251-8. doi: 10.1007/s002590050580.
5
99mTc Hynic-rh-Annexin V scintigraphy for in vivo imaging of apoptosis in patients with head and neck cancer treated with chemoradiotherapy.99mTc Hynic-rh-膜联蛋白V闪烁扫描术用于头颈部癌放化疗患者体内细胞凋亡成像
Eur J Nucl Med Mol Imaging. 2008 Mar;35(3):509-18. doi: 10.1007/s00259-007-0624-x. Epub 2007 Nov 10.
6
Structural requirements for in vivo detection of cell death with 99mTc-annexin V.用99mTc-膜联蛋白V进行体内细胞死亡检测的结构要求。
J Nucl Med. 2005 May;46(5):807-15.
7
99mTc-HYNIC-rh-annexin-V scintigraphy: visual and quantitative evaluation of early treatment-induced apoptosis to predict treatment outcome.99mTc-HYNIC-重组人膜联蛋白V闪烁扫描术：对早期治疗诱导的细胞凋亡进行视觉和定量评估以预测治疗结果。
Nucl Med Commun. 2008 Jan;29(1):39-44. doi: 10.1097/MNM.0b013e3282f1bc22.
8
Prognostic value of 99mTc-HYNIC annexin-V imaging in squamous cell carcinoma of the head and neck.99mTc-HYNIC膜联蛋白V显像在头颈部鳞状细胞癌中的预后价值
Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):47-52. doi: 10.1007/s00259-007-0577-0. Epub 2007 Sep 29.
9
Relationship of 99mTc-HYNIC annexin V uptake to microvessel density, FasL and MMP-9 expression, and the number of tumour-infiltrating lymphocytes in head and neck carcinoma.99mTc-HYNIC膜联蛋白V摄取与头颈部癌微血管密度、FasL和MMP-9表达以及肿瘤浸润淋巴细胞数量的关系
Eur J Nucl Med Mol Imaging. 2004 Jul;31(7):1016-21. doi: 10.1007/s00259-004-1499-8. Epub 2004 Mar 11.
10
Imaging of therapy-induced apoptosis using (99m)Tc-HYNIC-annexin V in thymoma tumor-bearing mice.用（99m）Tc-HYNIC-annexin V 对荷胸腺瘤小鼠进行治疗诱导细胞凋亡的影像学研究。
Cancer Biother Radiopharm. 2008 Dec;23(6):715-26. doi: 10.1089/cbr.2008.0504.

引用本文的文献

1
Interest and Limits of [F]ML-10 PET Imaging for Early Detection of Response to Conventional Chemotherapy.[F]ML-10正电子发射断层显像在早期检测对传统化疗反应中的应用价值与局限性
Front Oncol. 2021 Dec 20;11:789769. doi: 10.3389/fonc.2021.789769. eCollection 2021.
2
[F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer.[F]ML-10正电子发射断层显像（PET）成像无法在三阴性乳腺癌的临床前模型中评估对新辅助化疗的早期反应。
EJNMMI Res. 2020 Jan 6;10(1):2. doi: 10.1186/s13550-019-0587-5.
3
Avenues to molecular imaging of dying cells: Focus on cancer.

本文引用的文献

1
Prognostic significance of 99mTc Hynic-rh-annexin V scintigraphy during platinum-based chemotherapy in advanced lung cancer.99mTc 标记的 Hynic-重组人膜联蛋白 V 闪烁扫描术在晚期肺癌铂类化疗中的预后意义
J Clin Oncol. 2007 Jun 20;25(18):2534-9. doi: 10.1200/JCO.2006.10.1337.
2
99mTc-HYNIC Annexin-V imaging of tumors and its relationship to response to radiotherapy and/or chemotherapy.99mTc-HYNIC膜联蛋白V肿瘤显像及其与放疗和/或化疗反应的关系。
Q J Nucl Med Mol Imaging. 2007 Jun;51(2):182-8.
3
Sequential 99mTc-hydrazinonicotinamide-annexin V imaging for predicting response to chemotherapy.
濒死细胞的分子影像学途径：以癌症为例。
Med Res Rev. 2018 Sep;38(6):1713-1768. doi: 10.1002/med.21495. Epub 2018 Mar 12.
序贯99mTc-肼基烟酰胺-膜联蛋白V成像预测化疗反应
J Nucl Med. 2006 Nov;47(11):1813-8.
4
99mTc-annexin-V functional imaging of luminal thrombus activity in abdominal aortic aneurysms.99mTc-膜联蛋白V对腹主动脉瘤腔内血栓活性的功能成像
Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2153-9. doi: 10.1161/01.ATV.0000237605.25666.13. Epub 2006 Jul 20.
5
In vivo imaging of apoptosis in patients with acute stroke: correlation with blood-brain barrier permeability.急性中风患者体内细胞凋亡的成像：与血脑屏障通透性的相关性。
Brain Res. 2006 Aug 4;1103(1):13-9. doi: 10.1016/j.brainres.2006.05.073. Epub 2006 Jun 30.
6
Past, present, and future of annexin A5: from protein discovery to clinical applications.膜联蛋白A5的过去、现在与未来：从蛋白质发现到临床应用
J Nucl Med. 2005 Dec;46(12):2035-50.
7
In vivo imaging of apoptosis by 99mTc-Annexin V scintigraphy: visual analysis in relation to treatment response.通过99mTc-膜联蛋白V闪烁扫描术对细胞凋亡进行体内成像：与治疗反应相关的视觉分析
Radiother Oncol. 2004 Sep;72(3):333-9. doi: 10.1016/j.radonc.2004.07.008.
8
Apoptosis, autophagy, and more.细胞凋亡、自噬等等。
Int J Biochem Cell Biol. 2004 Dec;36(12):2405-19. doi: 10.1016/j.biocel.2004.04.011.
9
Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis.使用放射性标记的膜联蛋白A5对颈动脉粥样硬化患者斑块不稳定性进行无创检测。
N Engl J Med. 2004 Apr 1;350(14):1472-3. doi: 10.1056/NEJM200404013501425.
10
Molecular imaging of cancer: the basics.
Radiol Technol. 2003 Jul-Aug;74(6):486-97; quiz 498-500.