Shu Chih-Wen, Huang Chun-Ming
Institute of Biotechnology and Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
Clin Med Oncol. 2008;2:335-45. doi: 10.4137/cmo.s475. Epub 2008 Apr 24.
Heat shock proteins (HSPs) are a defined set of chaperones for maintaining proper functions of proteins. The HSP70 family, one of the most inducible families in response to stress, protects cells from stress-induced cell death. It has been documented that HSP70s are highly expressed in various types of cancer cells and make the cells resistant to adverse microenvironments, such as hypoxia and glucose starvation, which are common features in malignant progression. Over-expression of HSP70s is thus associated with tumor transformation and eventually results in a decrease of chemotherapy efficacy. Notably, the distribution of HSP70s is deregulated in cancer cells. It has been reported that HSP70s localize distinct organelles or are exported to humoral circulation during cancer development. Either surface or exported HSP70s play danger signals and trigger immune response to destroy the tumor cells. In this review, we lay out recent advances in the HSP70s-mediated cancer diagnosis and therapy. This review would be enlightening for clinical cancer medicine.
热休克蛋白（HSPs）是一组特定的伴侣蛋白，用于维持蛋白质的正常功能。HSP70家族是对应激反应最易诱导的家族之一，可保护细胞免受应激诱导的细胞死亡。已有文献记载，HSP70在各种类型的癌细胞中高度表达，并使细胞对不良微环境具有抗性，如缺氧和葡萄糖饥饿，这些都是恶性进展中的常见特征。因此，HSP70的过表达与肿瘤转化相关，并最终导致化疗疗效降低。值得注意的是，HSP70在癌细胞中的分布失调。据报道，在癌症发展过程中，HSP70定位于不同的细胞器或被分泌到体液循环中。表面或分泌的HSP70都作为危险信号并触发免疫反应以破坏肿瘤细胞。在本综述中，我们阐述了HSP70介导的癌症诊断和治疗的最新进展。本综述将为临床癌症医学提供启示。
