Tutar Yusuf
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Recent Pat DNA Gene Seq. 2011 Dec;5(3):214-8. doi: 10.2174/187221511797636293.
Hsp70 classes of molecular chaperones are highly conserved in all organisms and play an essential role in the maintenance of cellular homeostasis. Hsp70s assist nascent chain protein folding and denatured proteins, as well as the import of proteins to the organelles, and solubilization of aggregated proteins. ATPase function is required for Hsp70 function. Hsp70s use ATP hydrolysis driven mechanism for substrate protein binding and release. Various Hsps are unregulated in cancers but their significance for tumor growth is poorly understood. Studies have linked Hsp70 to several types of carcinoma. Human Hsp70s allow proliferation of cancer cells and suppress apoptotic and senescence pathways. This review presents Hsp70s role for growth of transformed cells and the current state of Hsp70 as a drug target along with recent patents in humans in this particular area.
热休克蛋白70（Hsp70）家族的分子伴侣在所有生物体中高度保守，在维持细胞内稳态方面发挥着至关重要的作用。Hsp70协助新生链蛋白折叠和变性蛋白，以及蛋白质向细胞器的转运和聚集蛋白的溶解。Hsp70的功能需要ATP酶活性。Hsp70利用ATP水解驱动的机制来结合和释放底物蛋白。各种热休克蛋白（Hsps）在癌症中表达失调，但其对肿瘤生长的意义却知之甚少。研究已将Hsp70与多种类型的癌症联系起来。人类Hsp70可促进癌细胞增殖，并抑制凋亡和衰老途径。本综述介绍了Hsp70在转化细胞生长中的作用，以及Hsp70作为药物靶点的现状，以及该特定领域最近的人类专利。
