乳腺癌患者的骨髓微转移：一项长期随访研究。
Bone Marrow Micrometastases in Breast Cancer Patients: A Long-Term Follow-up Study.
作者信息
Molino Annamaria, Giovannini Monica, Micciolo Rocco, Auriemma Alessandra, Fiorio Elena, Santo Antonio, Cetto Gian Luigi
机构信息
Department of Medical Oncology, University of Verona, Verona, Italy.
出版信息
Clin Med Oncol. 2008;2:487-90. Epub 2008 Sep 4.
Abstract
In 125 early breast cancer patients who underwent multiple bone marrow aspirates, there was no significant difference in terms of disease-free and overall survival after a median follow-up of 163 months between the patients with or without micrometastasis at the time of primary surgery. However, when the time-dependent evolution of the bone marrow aspirates was taken into account, some evidence for a longer disease-free and overall survival was found for the patients with negative bone marrow.
摘要
在125例接受多次骨髓穿刺的早期乳腺癌患者中，在对主要手术时有无微转移的患者进行了163个月的中位随访后，其无病生存期和总生存期并无显著差异。然而，当考虑骨髓穿刺的时间依赖性演变时，发现骨髓阴性的患者有更长无病生存期和总生存期的一些证据。
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本文引用的文献
1
Bone marrow cells in the 'pre-metastatic niche': within bone and beyond.
Cancer Metastasis Rev. 2006 Dec;25(4):521-9. doi: 10.1007/s10555-006-9036-9.
2
The clinical significance of disseminated tumor cells in breast cancer.
Nat Clin Pract Oncol. 2007 Jan;4(1):30-41. doi: 10.1038/ncponc0685.
3
Significance, detection and markers of disseminated breast cancer cells.
Endocr Relat Cancer. 2006 Dec;13(4):1033-67. doi: 10.1677/ERC-06-0001.
4
Recent translational research: circulating tumor cells in breast cancer patients.
Breast Cancer Res. 2006;8(5):110. doi: 10.1186/bcr1541.
5
Disseminated tumor cells in breast cancer: detection, characterization and clinical relevance.
Future Oncol. 2006 Aug;2(4):553-61. doi: 10.2217/14796694.2.4.553.
6
Prognostic significance of disseminated tumor cells as detected by quantitative real-time reverse-transcriptase polymerase chain reaction in patients with breast cancer.
Clin Breast Cancer. 2006 Jun;7(2):146-52. doi: 10.3816/CBC.2006.n.024.
7
The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer.
Biomed Pharmacother. 2005 Oct;59 Suppl 2:S384-6. doi: 10.1016/s0753-3322(05)80084-8.
8
Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer.
Br J Cancer. 2006 Mar 13;94(5):672-80. doi: 10.1038/sj.bjc.6602985.
9
Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 265 primary breast carcinomas.
Breast Cancer Res. 2005;7(6):R1174-85. doi: 10.1186/bcr1360. Epub 2005 Nov 24.
10
A pooled analysis of bone marrow micrometastasis in breast cancer.
N Engl J Med. 2005 Aug 25;353(8):793-802. doi: 10.1056/NEJMoa050434.
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