Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Chem Commun (Camb). 2011 Oct 14;47(38):10686-8. doi: 10.1039/c1cc14230e. Epub 2011 Sep 5.
Thioflavin T (ThT) is a molecular-rotor-type fluorophore reputed for the selective binding to amyloid fibrils. Using induced circular dichroism, here we show that ThT binds in an orderly manner to α-helical poly-L-glutamic acid (PLGA) implying that neither stacked β-sheets nor π-π stacking interactions are necessary for the binding between the dye and proteins.
硫黄素 T（ThT）是一种分子转子型荧光团，据称可选择性结合淀粉样纤维。在这里，我们使用诱导圆二色性表明，ThT 以有序的方式与 α-螺旋聚 L-谷氨酸（PLGA）结合，这表明染料与蛋白质之间的结合既不需要堆叠的 β-片层也不需要 π-π 堆积相互作用。
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