基于肽核酸入侵的 DNA 扭结的符号和大小的精确工程和可视化。
Precise engineering and visualization of signs and magnitudes of DNA writhe on the basis of PNA invasion.
机构信息
RecDivision of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore.
出版信息
Chem Commun (Camb). 2011 Oct 14;47(38):10695-7. doi: 10.1039/c1cc13158c. Epub 2011 Sep 5.
PMID:21892494
Abstract
It is demonstrated that the right and left handedness of DNA supercoils can be engineered precisely and readily at the molecular level in vitro through utilization of the invading property of peptide nucleic acid.
摘要
研究表明，通过利用肽核酸的侵入特性，可以在体外分子水平上精确且容易地设计 DNA 超螺旋的右旋和左旋。
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