通过原位生成的硫代酸的点击反应及其在动力学靶向合成中的应用。
Sulfo-click reaction via in situ generated thioacids and its application in kinetic target-guided synthesis.
机构信息
Department of Chemistry, University of South Florida, 4202 E Fowler Ave., Tampa, FL 33620, USA.
出版信息
Chem Commun (Camb). 2012 Feb 1;48(10):1526-8. doi: 10.1039/c1cc14724b. Epub 2011 Sep 5.
PMID:21892513
Abstract
Herein, we describe a practical, one-pot variant of the sulfo-click reaction, in which 9-fluorenylmethyl-protected thioesters are rapidly deprotected and reacted further with sulfonylazides to give N-acyl sulfonamides.
摘要
在此，我们描述了磺酰基点击反应的一种实用的一锅法变体，其中 9-芴基甲氧基羰基保护的硫酯可迅速脱保护，并与磺酰基叠氮进一步反应，生成 N-酰基磺酰胺。
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