Fronie A, Dumitrescu Daniela, Vască V, Fronie Anca Simona
Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, Romania.
Rom J Morphol Embryol. 2011;52(3):831-5.
Besides lesions considered to be premalignant (such as erythroplasia, Bowen disease), a number of other potentially malignant lesions with higher or lower degree of epithelial dysplasia depending on the keratinization degree or determined by the action of carcinogens and irritants substances are described in the oral mucosa. Although they are practically considered the most harmless formations located on the oral mucosa, papillomas and condylomas are also the most frequent. In this study (conducted on a total of 38 cases with benign neoplasia) we planned a histopathological evaluation of surgical excision samples obtained from interventions on lingual neoplasias and harvested from the areas most exposed to chronic trauma or the areas in direct contact with mechanical irritants, in order to determine the histopathological pattern of the different types of histopathological lesions, the possible presence of keratosis-type changes or even possible dysplasias.
除了被认为是癌前病变的损害（如红斑、鲍温病）外，口腔黏膜中还描述了一些其他潜在恶性病变，这些病变根据角化程度或由致癌物和刺激性物质的作用决定，具有程度高低不同的上皮发育异常。虽然乳头状瘤和尖锐湿疣实际上被认为是口腔黏膜上最无害的结构，但它们也是最常见的。在本研究中（共对38例良性肿瘤患者进行），我们计划对从舌部肿瘤手术切除样本进行组织病理学评估，这些样本取自最易遭受慢性创伤的区域或与机械刺激直接接触的区域，以确定不同类型组织病理学病变的组织病理学模式、是否存在角化病样改变甚至可能的发育异常。
