Division of Pediatric Nephrology, Department of Pediatrics & Communicable Diseases, University of Michigan, F6865 Mott Hospital/SPC 5297, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5297, USA.
Pediatr Nephrol. 2011 Dec;26(12):2249-51. doi: 10.1007/s00467-011-1994-7. Epub 2011 Sep 4.
Secondary membranous nephropathy (MN) associated with malignancy is not uncommon in adults, but it is rare in children. We report a 6-year-old girl who developed nephrotic-range proteinuria following diagnosis of a Sertoli-Leydig ovarian tumor. A renal biopsy was performed, which led to the diagnosis of MN. The patient maintained normal renal function and gradually showed improvement in proteinuria over several months without the use of corticosteroids or angiotensin-converting enzyme inhibitors. Our case highlights the importance of performing screening urinalyses in children with tumors to recognize the presence of clinically significant, but potentially asymptomatic kidney disease.
继发性膜性肾病(MN)与恶性肿瘤相关在成人中并不罕见,但在儿童中很少见。我们报告了一例 6 岁女孩,在诊断出 Sertoli-Leydig 卵巢肿瘤后出现肾病范围的蛋白尿。进行了肾活检,诊断为 MN。该患者的肾功能正常,蛋白尿在数月内逐渐改善,未使用皮质类固醇或血管紧张素转换酶抑制剂。我们的病例强调了对患有肿瘤的儿童进行筛查性尿液分析的重要性,以识别存在潜在无症状但具有临床意义的肾脏疾病。