一种制备低接枝度聚乳酸生物可降解壳聚糖衍生物的简便方法。
A facile method for preparing biodegradable chitosan derivatives with low grafting degree of poly(lactic acid).
机构信息
College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China.
出版信息
Int J Biol Macromol. 2011 Dec 1;49(5):1016-21. doi: 10.1016/j.ijbiomac.2011.08.022. Epub 2011 Aug 27.
Chemical modification of chitosan by grafting with PLA (CS-g-PLA) was developed via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) mediated coupling reaction. The introduction of PLA disrupted the crystalline structure of chitosan, improved its solubility and thermal stability. Low degree of PLA substitution showed better degradation efficiency than chitosan and PLA. Weight loss of CS-g-PLA6 and CS-g-PLA4 was 87% and 94%, respectively, in 7 days enzymatic degradation study. CS-g-PLA2 was totally degraded in 1 day. Self-assembly behavior was studied using pyrene fluorescence dye technique and found to be PLA grafting level dependent. CS-g-PLA with low grafting degree showed hydrophilic, self-assembling properties and controllable biodegradability that may widen its applications.
通过 1-乙基-3-(3-二甲基氨基丙基)碳二亚胺（EDC）介导的偶联反应，对壳聚糖进行了与 PLA（CS-g-PLA）的接枝化学修饰。PLA 的引入破坏了壳聚糖的结晶结构，提高了其溶解度和热稳定性。低取代度的 PLA 比壳聚糖和 PLA 具有更好的降解效率。在 7 天的酶降解研究中，CS-g-PLA6 和 CS-g-PLA4 的失重率分别为 87%和 94%。CS-g-PLA2 在 1 天内完全降解。使用芘荧光染料技术研究了自组装行为，发现其与 PLA 接枝水平有关。具有低接枝度的 CS-g-PLA 具有亲水性、自组装特性和可控的生物降解性，这可能拓宽其应用范围。
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