Sánchez-Pulgarín M, Martínez-de-la-Casa J M, Escalada A, Sáenz-Francés F, García-Feijoó J, García Sánchez J
Departamento de Glaucoma, Hospital Clínico San Carlos, Madrid, España.
Arch Soc Esp Oftalmol. 2011 Sep;86(9):282-6. doi: 10.1016/j.oftal.2011.04.011. Epub 2011 Jul 22.
To study compliance in the medical treatment of glaucoma, its possible association with other factors, and quality of life of patients with glaucoma.
Longitudinal prospective study of 60 patients with ocular hypertension or glaucoma who were treated with travoprost, or with a fixed combination of travoprost/timolol nightly. All subjects were given a Travalert(®) dosing aid and were reviewed after one and four months. Strict and relative compliance data were collected on each visit. The relationship between compliance and other variables was studied using univariate analysis. To analyse quality of life, patients were given self-assessment STAI anxiety questionnaires after the first and last visits.
Relative compliance for the four months was significantly greater than the strict compliance (P=.001). In the group of least compliance the number of patients on treatment with combination therapy was significantly higher than those on monotherapy. In the lost cases, the number of men was significantly higher than women. No association was found in the other variables. The anxiety was similar to that in the normal population.
Compliance is very important in the treatment of glaucoma, and our study provides objective data through the use of Travalert dosing aid with relative compliances of 70%. Patients with combined therapies have lower compliance than those on monotherapy.
研究青光眼药物治疗的依从性、其与其他因素的可能关联以及青光眼患者的生活质量。
对60例高眼压症或青光眼患者进行纵向前瞻性研究，这些患者接受曲伏前列素治疗，或每晚使用曲伏前列素/噻吗洛尔固定复方制剂治疗。所有受试者均使用Travalert®给药辅助工具，并在1个月和4个月后进行复查。每次就诊时收集严格依从性和相对依从性数据。使用单变量分析研究依从性与其他变量之间的关系。为分析生活质量，在首次和末次就诊后让患者填写自我评估的STAI焦虑问卷。
四个月的相对依从性显著高于严格依从性（P = 0.001）。在依从性最低的组中，接受联合治疗的患者数量显著高于接受单一疗法的患者。在失访病例中，男性数量显著高于女性。在其他变量中未发现关联。焦虑情况与正常人群相似。
依从性在青光眼治疗中非常重要，我们的研究通过使用Travalert给药辅助工具提供了客观数据，相对依从率为70%。联合治疗的患者依从性低于单一疗法的患者。
