Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Maturitas. 2011 Nov;70(3):261-5. doi: 10.1016/j.maturitas.2011.08.001. Epub 2011 Sep 4.
Prophylactic salpingo-oophorectomy is recommended to women who carry a BRCA1 or BRCA2 mutation at age 35 or after childbearing is complete. This procedure is the mainstay of ovarian and fallopian tube cancer prevention in these women. Therefore an understanding of the short and long-term impact of the surgery is essential. Salpingo-oophorectomy, particularly when done prior to natural menopause, may impact on several aspects of quality of life and health. The health benefits of this surgery (cancer prevention) should outweigh the costs of the procedure in terms of quality of life and long term health. In this review, the impact of this surgery on quality of life and health in women who carry a BRCA mutation is discussed. Preliminary studies have focused on short-term effects, such as quality of life. In the short term, overall quality of life appears to be similar before and after surgery, however vasomotor symptoms related to surgical menopause and changes in sexual functioning are common. HRT appears to mitigate some but not all of these symptoms. Women report high levels of satisfaction with their decision to have the surgery despite the impact of prophylactic salpingo-oophorectomy. Studies of the long term health and quality of life after salpingo-oophorectomy in women who carry a BRCA mutation have not yet been published.
预防性输卵管卵巢切除术推荐用于 35 岁或完成生育后携带 BRCA1 或 BRCA2 突变的女性。该手术是预防这些女性卵巢和输卵管癌的主要方法。因此，了解手术的短期和长期影响至关重要。输卵管卵巢切除术，特别是在自然绝经前进行，可能会对生活质量和健康的几个方面产生影响。该手术的健康益处（预防癌症）应超过手术对生活质量和长期健康的影响。在这篇综述中，讨论了携带 BRCA 突变的女性进行该手术对生活质量和健康的影响。初步研究集中在短期影响，如生活质量。在短期内，手术前后的总体生活质量似乎相似，但与手术性绝经相关的血管舒缩症状和性功能变化很常见。HRT 似乎减轻了其中的一些症状，但不是全部。尽管预防性输卵管卵巢切除术有影响，但女性对手术决定的满意度很高。尚未发表关于携带 BRCA 突变的女性进行输卵管卵巢切除术后长期健康和生活质量的研究。
