Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Cells. 2022 Feb 4;11(3):539. doi: 10.3390/cells11030539.
Besides and , several other inheritable mutations have been identified that increase ovarian cancer risk. Surgical excision of the fallopian tubes and ovaries reduces ovarian cancer risk, but for some non- hereditary ovarian cancer mutations the benefit of this intervention is unclear. The fallopian tubes of women with hereditary ovarian cancer mutations provide many insights into the early events of carcinogenesis and process of malignant transformation. Here we review cancer pathogenesis in hereditary cases of ovarian cancer, the occurrence of pre-invasive lesions and occult carcinoma in mutation carriers and their clinical management.
除了 BRCA1 和 BRCA2 之外，还有其他几种可遗传的突变被确定会增加卵巢癌的风险。手术切除输卵管和卵巢可以降低卵巢癌的风险，但对于某些非遗传性卵巢癌突变，这种干预的益处尚不清楚。携带遗传性卵巢癌突变的女性的输卵管为研究癌变的早期事件和恶性转化过程提供了许多启示。在这里，我们回顾了遗传性卵巢癌病例中的癌症发病机制、突变携带者中前浸润性病变和隐匿性癌的发生以及它们的临床管理。
