Service d'Anatomie et Cytologie Pathologiques, Hôpital Cochin, Université Paris Descartes, Paris, France.
Dig Liver Dis. 2011 Dec;43(12):971-4. doi: 10.1016/j.dld.2011.07.013. Epub 2011 Sep 3.
Acinar cell carcinomas of the pancreas are rare neoplasms. Usually diagnosed at an advanced stage, in general they are large solid pancreatic tumours with an average size of more than 10 cm.
We report 3 cases of acinar cell carcinomas involving the peripancreatic lymph nodes, the liver hilum and the colon respectively, without clinical or pathological evidence of pancreatic tumours. These highly cellular neoplasms showed a predominantly acinar cell differentiation intermingled with a ductal component, with intracellular or extracellular mucin production by at least 25% of tumour cells. In addition, one case showed endocrine differentiation. Diffuse immunoreactivity for acinar enzymes trypsin and chymotrypsin was present in all cases.
The occurrence of acinar cell carcinomas outside the pancreas underlines the notion that acinar cell carcinomas may originate in extrapancreatic sites and probably develop from heterotopic or metaplastic pancreatic foci present along the biliary tract.
胰腺腺泡细胞癌是罕见的肿瘤。通常在晚期诊断，通常为 10cm 以上的大实性胰腺肿瘤。
我们报告了 3 例分别累及胰周淋巴结、肝门和结肠的胰腺腺泡细胞癌，无胰腺肿瘤的临床或病理证据。这些高细胞性肿瘤主要表现为腺泡细胞分化，伴有导管成分，至少 25%的肿瘤细胞有细胞内或细胞外黏蛋白产生。此外，有 1 例显示内分泌分化。所有病例均弥漫表达腺酶胰蛋白酶和糜蛋白酶。
胰腺外发生的胰腺腺泡细胞癌提示胰腺腺泡细胞癌可能起源于胰外部位，可能由沿胆道存在的异位或化生的胰腺灶发展而来。
