治疗性疫苗治疗慢性疾病：成功与技术挑战。
Therapeutic vaccines for chronic diseases: successes and technical challenges.
机构信息
Cytos Biotechnology AG, Wagistrasse 25, 8952 Zuerich-Schlieren, Switzerland.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2815-22. doi: 10.1098/rstb.2011.0103.
Abstract
Chronic, non-communicable diseases are the major cause of death and disability worldwide and have replaced infectious diseases as the major burden of society in large parts of the world. Despite the complexity of chronic diseases, relatively few predisposing risk factors have been identified by the World Health Organization. Those include smoking, alcohol abuse, obesity, high cholesterol and high blood pressure as the cause of many of these chronic conditions. Here, we discuss several examples of vaccines that target these risk factors with the aim of preventing the associated diseases and some of the challenges they face.
摘要
慢性非传染性疾病是全球范围内死亡和残疾的主要原因，已取代传染病成为世界大部分地区社会的主要负担。尽管慢性疾病较为复杂，但世界卫生组织仅确定了相对较少的致病危险因素。这些因素包括吸烟、酗酒、肥胖、高胆固醇和高血压，它们是许多这类慢性疾病的病因。在这里，我们讨论了几种针对这些危险因素的疫苗，旨在预防相关疾病及其面临的一些挑战。
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