内皮素与肾血管系统。
Endothelin and the renal vasculature.
作者信息
Guan Zhengrong, Inscho Edward W
出版信息
Contrib Nephrol. 2011;172:35-49. doi: 10.1159/000328720. Epub 2011 Aug 30.
Abstract
The endothelin (ET) system comprises a family of three isopeptides (ET-1, ET-2, and ET-3)involved in diverse physiological and pathophysiological events. ET-1 is the major renal peptide that exerts its biological activity by binding to ET(A) and ET(B) receptors. Both ET(A) and ET(B) receptors are expressed by renal microvascular smooth muscle cells, where activation causes vasoconstriction. ET(B) receptors are also expressed by microvascular endothelial cells, where activation leads to vasodilator responses. ET-1 influences preglomerular and postglomerular microvascular tone and thus can significantly influence renal hemodynamics. Alteration of renal ET-1 synthesis and receptor expression has been reported in cardiovascular diseases, and could contribute to renal injury by altering renal microvascular reactivity. In this brief review, we will try to summarize what is known about ET control of renal microvascular function.
摘要
内皮素（ET）系统由三种异肽（ET-1、ET-2和ET-3）组成，参与多种生理和病理生理过程。ET-1是主要的肾脏肽，通过与ET(A)和ET(B)受体结合发挥其生物活性。ET(A)和ET(B)受体均由肾微血管平滑肌细胞表达，在这些细胞中激活会导致血管收缩。ET(B)受体也由微血管内皮细胞表达，在这些细胞中激活会导致血管舒张反应。ET-1影响肾小球前和肾小球后微血管张力，因此可显著影响肾脏血流动力学。在心血管疾病中已报道肾脏ET-1合成和受体表达的改变，并且可能通过改变肾微血管反应性导致肾损伤。在这篇简短的综述中，我们将尝试总结关于ET对肾微血管功能控制的已知情况。
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