Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, People's Republic of China.
J Mater Sci Mater Med. 2011 Nov;22(11):2487-96. doi: 10.1007/s10856-011-4432-2. Epub 2011 Sep 6.
To develop high macroporous and degradable bone cements which can be used as the substitute of bone repairing and drug carriers, cross-linked gelatin microspheres (GMs) and calcium sulfate dihydrate (CSD) powder were incorporated into calcium phosphate bone cement (CPC) to induce macropores, adjust drug release and control setting time of α-TCP-liquid mixtures after degradation of GMs and dissolution of CSD. In this study, CSD was introduced into CPC/10GMs composites to offset the prolonged setting time caused by the incorporation of GMs, and gentamicin sulphate (GS) was chosen as the model drug entrapped within the GMs. The effects of CSD amount on the cement properties, drug release ability and final macroporosity after GMs degradation were studied in comparison with CPC/GMs cements. The resulting cements presented reduced setting time and increased compressive strength as the content of CSD below 5 wt%. Sustained release of GS was obtained on at least 21 days, and release rates were found to be chiefly controlled by the GMs degradation rate. After 4 weeks of degradation study, the resulting composite cements appeared macroporous, degradable and suitable compressive strength, suggesting that they have potential as controlled local drug delivery system and for cancellous bone applications.
为了开发出可作为骨修复和药物载体替代物的高微孔和可降解骨水泥，交联明胶微球（GMs）和二水硫酸钙（CSD）粉末被掺入磷酸钙骨水泥（CPC）中，以诱导大孔、调整药物释放并控制 GM 降解和 CSD 溶解后 α-TCP 液体混合物的凝固时间。在这项研究中，CSD 被引入到 CPC/10GMs 复合材料中，以抵消 GMs 掺入引起的凝固时间延长，硫酸庆大霉素（GS）被选为被 GMs 包埋的模型药物。研究了 CSD 用量对水泥性能、药物释放能力和 GM 降解后最终大孔率的影响，并与 CPC/GMs 水泥进行了比较。结果表明，当 CSD 含量低于 5wt%时，水泥的凝固时间缩短，抗压强度增加。GS 的持续释放至少持续 21 天，释放速率主要由 GMs 的降解速率控制。在 4 周的降解研究后，所得复合水泥呈现出大孔、可降解和适宜的抗压强度，表明它们具有作为局部药物控释系统和松质骨应用的潜力。
