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通过仿生矿化胶原蛋白油灰强化的锁定系统用于治疗骨质疏松性肱骨近端骨折。

Locking system strengthened by biomimetic mineralized collagen putty for the treatment of osteoporotic proximal humeral fractures.

作者信息

Peng Cheng, Wang Hai-Peng, Yan Jia-Hua, Song Tian-Xi

机构信息

Department of Orthopaedics, Jing'an District Centre Hospital, Jing'an Branch, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.

Beijing Allgens Medical Science and Technology Co., Ltd., Beijing 100176, China.

出版信息

Regen Biomater. 2017 Oct;4(5):289-294. doi: 10.1093/rb/rbx016. Epub 2017 Jul 21.

Abstract

The current study is to observe the effect of the locking system strengthened by biomimetic mineralized collagen putty for the treatment of senile proximal humeral osteoporotic fractures. From January 2012 to December 2015, 80 cases of senile patients with osteoporotic proximal humeral fractures were randomly divided into an observation group and a control group, each group with a total of 40 cases. The control group was simply treated with locking plate. The observation group was treated with locking plate in combination with biomimetic mineralized collagen putty. The therapeutic effect thereby was observed. The excellent and satisfactory rate was 90% in observation group and was 72.5% in control group. The difference between the two groups was statistically significant (χ = 5.3312, < 0.05). The fracture healing time was 11.82 ± 3.62 weeks in observation group and 19.78 ± 5.46 weeks in control group. The shoulder joint function score was 89.63 ± 8.12 in observation group and 76.92 ± 8.18 in control group. There was significant difference between the two groups (= 7.1272; 12.7834, < 0.05). The complication rate was 10% in the observation group and 32.5% in the control group (χ = 7.3786, < 0.05). Locking system strengthened by biomimetic mineralized collagen putty has advantages such as accelerating healing of senile proximal humeral fracture, improving the therapeutic effect, reducing the complications. As one of the optimal internal fixation method, it provides a new option for better treatment of senile osteoporotic fracture.

摘要

本研究旨在观察仿生矿化胶原骨泥强化锁定系统治疗老年肱骨近端骨质疏松性骨折的效果。2012年1月至2015年12月,将80例老年肱骨近端骨质疏松性骨折患者随机分为观察组和对照组,每组各40例。对照组单纯采用锁定钢板治疗,观察组采用锁定钢板联合仿生矿化胶原骨泥治疗,观察其治疗效果。观察组优良率为90%,对照组为72.5%,两组差异有统计学意义(χ = 5.3312,P < 0.05)。观察组骨折愈合时间为(11.82 ± 3.62)周,对照组为(19.78 ± 5.46)周。观察组肩关节功能评分为(89.63 ± 8.12)分,对照组为(76.92 ± 8.18)分,两组差异有统计学意义(t = 7.1272;t = 12.7834,P < 0.05)。观察组并发症发生率为10%,对照组为32.5%(χ = 7.3786,P < 0.05)。仿生矿化胶原骨泥强化锁定系统具有促进老年肱骨近端骨折愈合、提高治疗效果、减少并发症等优点,作为一种理想的内固定方法之一,为老年骨质疏松性骨折的更好治疗提供了新的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/929e/5633693/fe995b254d31/rbx016f1.jpg

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