Zhu Feng, Ai Bing-Wei, Gao Jian-Yun
Department of Acupuncture and Moxibustion, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, Jiangsu Province, China.
Zhongguo Zhen Jiu. 2011 Aug;31(8):721-6.
To explore the effects and mechanism of electroacupuncture combined with medium frequency therapy on lumbar nerve root compression.
Seventy-two Sprague-Dawley (SD) rats were randomly divided into a normal group, a sham operation group, a model group, an electroacupuncture group (EA group), a medium frequency group(MF group) and an electroacupuncture combined with medium frequency group (EA + MF group), twelve rats in each group. Models were established by surgery except the normal group and the sham operation group. Rats in the normal group, the sham operation group and the model group were not treated. In the EA group, the rats were treated by electroacupuncture at "Jiaji" (EX-B 2) and "Huantiao" (GB 30) etc., and by medium frequency at the "Jiaji" (EX-B 2) and "Huantiao"(GB 30) in the MF group. Rats in the EA + MF group were treated by both electroacupuncture and medium frequency. All treatments were started on the fifth day of established model, once a day for fourteen days. Rats' lower limb functions were observed before and after treatment, thromboxane B 2 (TXB 2) and prostacyclin F1alpha (PGF1alpha) in blood plasma were tested after treatment, and pathological changes in the local compressed nerve root were observed by light microscope.
After treatment, the scores of rats' lower limb neurologic function in three therapy groups were significantly lower than before (all P < 0.01). Compared with the model group, TXB 2 in the EA group and the EA + MF group after treatment were decreased significantly (both P < 0.01), and PGF1alpha in the EA + MF group was increased significantly (P < 0.01), and TXB 2/PGF1alpha level were all regulated favorably in three therapy groups (all P < 0.01), and the pathological scores in the EA group and the EA + MF group were improved significantly (both P < 0.01).
n Electroacupuncture combined with medium frequency has anti-inflammatory and analgesic effects in model rats with lumbar nerve root compression, and its mechanism may be related with the regulation of homeostasis M between TXB 2 and PGF1alpha so as to improve microcirculation.
探讨电针结合中频治疗对腰神经根受压的影响及机制。
将72只Sprague-Dawley（SD）大鼠随机分为正常组、假手术组、模型组、电针组（EA组）、中频组（MF组）和电针结合中频组（EA + MF组），每组12只。除正常组和假手术组外，其余各组均通过手术建立模型。正常组、假手术组和模型组大鼠不进行处理。EA组大鼠于“夹脊”（EX-B 2）、“环跳”（GB 30）等穴位行电针治疗，MF组大鼠于“夹脊”（EX-B 2）、“环跳”（GB 30）行中频治疗。EA + MF组大鼠同时接受电针和中频治疗。所有治疗均于造模后第5天开始，每日1次，共14天。观察治疗前后大鼠下肢功能，治疗后检测血浆血栓素B 2（TXB 2）和前列环素F1α（PGF1α）水平，光镜下观察局部受压神经根的病理变化。
治疗后，三个治疗组大鼠下肢神经功能评分均显著低于治疗前（均P < 0.01）。与模型组比较，EA组和EA + MF组治疗后TXB 2水平显著降低（均P < 0.01），EA + MF组PGF1α水平显著升高（P < 0.01），三个治疗组TXB 2/PGF1α水平均得到良好调节（均P < 0.01），EA组和EA + MF组病理评分显著改善（均P < 0.01）。
电针结合中频对腰神经根受压模型大鼠具有抗炎、镇痛作用，其机制可能与调节TXB 2和PGF1α之间的内环境稳态从而改善微循环有关。
