[根据俄罗斯血液学中心研究组ALL - 2009方案对成人Ph阴性急性淋巴细胞白血病进行治疗的初步结果]

[First results of Ph-negative acute lymphoblastic leukemia therapy of adults according to the protocol of Research Group of Russian Hematological Centers ALL-2009].

作者信息

Parovichnikova E N, Kliasova G A, Isaev V G, Sokolov A N, Kokhno A V, Troitskaia V V, Mavrina E V, Khodunova E E, Ustinova E N, Gribanova E O, Kravchenko S K, Ryzhko V V, Kaporskaia T S, Baranova O Iu, Bondarenkko S N, Nizametdinova A S, Kondakova E V, Ryl'tsova T V, Alufer'eva A N, Samoĭlova O S, Skamorina O P, Gavrilova L V, Pristupa A S, Vopilina N A, Konstantinova T S, Kriuchkova I V, Anchukova L V, Tikunova T S, Kaplanov K D, Lapin V A, Tumakov V A, Kozmina M N, Chernysh S A, Podol'tseva E I, Kulikov S M, Davidian Iu R, Savchenko V G

出版信息

Ter Arkh. 2011;83(7):11-7.

PMID:21894746

Abstract

AIM

To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.

MATERIAL AND METHODS

Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.

RESULTS

Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.

CONCLUSION

Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.

摘要

目的

回顾执行成人急性Ph阴性淋巴细胞白血病ALL - 2009治疗方案两年的经验结果。

材料与方法

在2008年11月至2010年12月登记参加本研究的111例患者中，分析涵盖了来自俄罗斯联邦18个城镇23个血液学中心的96例患者。

结果

按照ALL - 2009方案进行治疗，91.2%的患者实现了完全缓解，早期低致死率为5.5%。缓解后致死率降至3.7%，而之前的研究为22%。总体两年生存率和无复发生存率分别达到77.6%和78.4%。任何染色体畸变的检测对无复发生存率有显著影响：核型正常的患者为74%，而核型异常的患者为100%。