Levine E G, Bloomfield C D
Department of Medicine, Roswell Park Memorial Institute, Buffalo, N.Y. 14263.
J Natl Cancer Inst Monogr. 1990(10):7-12.
In the non-Hodgkin's lymphoma (NHL), recurring cytogenetic abnormalities have been identified, and significant correlations among them and morphology, immunophenotyping, and parameters of clinical outcome have been recognized. The structural involvement of the 14q32 band is substantially more frequent than are other common abnormalities, which include del(6q), i(17q), +3, +7, +12, +18, and +21. Twenty-two recurring translocations have been identified. Almost three-fourths of all breakpoints in NHL occur at sites to which lineage-determining, transformation-related genes, or fragile sites have been mapped. Besides the well-known association of the t(14;18) (q32;q21) with the follicular histologies and t(8;14)(q24;q32) with small non-cleaved cell lymphoma, several other associations between recurring cytogenetic abnormalities and morphologic subtypes have been found. Similarly, several associations between cytogenetic abnormalities and the B or T immunophenotype have been delineated. Trisomy 3 or duplications of 3p predict a favorable clinical outcome; trisomy 2 or duplication 2p and abnormalities of chromosome 17 predict a poor prognosis. Common sequential changes include a (second) 14q32 break and abnormalities of chromosomes 1 and 2. Continuing work in these areas will serve to identify more clearly those regions of the genome important to transformation, differentiation, clinical aggressiveness, and progression in NHL.
在非霍奇金淋巴瘤（NHL）中，已识别出复发性细胞遗传学异常，并且已认识到它们与形态学、免疫表型及临床结局参数之间存在显著相关性。14q32带的结构受累比其他常见异常更为频繁，其他常见异常包括del(6q)、i(17q)、+3、+7、+12、+18和+21。已识别出22种复发性易位。NHL中几乎四分之三的所有断点都发生在已定位了谱系决定基因、转化相关基因或脆性位点的区域。除了众所周知的t(14;18)(q32;q21)与滤泡性组织学以及t(8;14)(q24;q32)与小无裂细胞淋巴瘤的关联外，还发现了复发性细胞遗传学异常与形态学亚型之间的其他几种关联。同样，细胞遗传学异常与B或T免疫表型之间的几种关联也已被描绘出来。三体3或3p重复预示着良好的临床结局；三体2或2p重复以及17号染色体异常预示着预后不良。常见的顺序性变化包括（第二次）14q32断裂以及1号和2号染色体异常。在这些领域持续开展的工作将有助于更清楚地识别基因组中对NHL的转化、分化、临床侵袭性和进展重要的那些区域。
