响应型双光子诱导铕发射作为麻痹性贝类毒素的荧光指示剂。

Responsive two-photon induced europium emission as fluorescent indicator for paralytic shellfish saxitoxin.

机构信息

Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China.

出版信息

Org Lett. 2011 Oct 7;13(19):5036-9. doi: 10.1021/ol2018246. Epub 2011 Sep 6.

DOI:10.1021/ol2018246

PMID:21894946

Abstract

A water-soluble europium(III) complex (1) has been synthesized and demonstrated to be a specific fluorescence probe for the paralytic shellfish toxin saxitoxin, a neurotoxin that blocks the voltage-gated sodium channels on cell membranes. Saxitoxin binds to the europium complex (K(B) = 6.1 × 10(4) M(-1)) and triggers a two-photon induced f-f emission enhancement by over 100% and increases the two-photon absorption cross-section from 9 to 36 GM.

摘要

一种水溶性铕(III)配合物(1)已被合成，并被证明是一种特定的荧光探针，用于麻痹性贝类毒素石房蛤毒素，这是一种阻断细胞膜上电压门控钠离子通道的神经毒素。石房蛤毒素与铕配合物结合（K(B) = 6.1 × 10(4) M(-1)），并通过超过 100%的双光子诱导 f-f 发射增强，将双光子吸收截面从 9 增加到 36 GM。