杏仁油对大鼠心肌缺血再灌注损伤的保护作用。
Protective effects of apricot kernel oil on myocardium against ischemia-reperfusion injury in rats.
机构信息
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.
出版信息
Food Chem Toxicol. 2011 Dec;49(12):3136-41. doi: 10.1016/j.fct.2011.08.015. Epub 2011 Aug 27.
The present study was undertaken to evaluate the potential cardioprotective effects of apricot kernel oil (AO) on the myocardial ischemia-reperfusion (IR) of rat model in vivo. The rats were divided into five groups: sham-operated, IR, low dose AO-treated IR (LD-AO+IR), medium dose AO-treated IR (MD-AO+IR) and high dose AO-treated IR (HD-AO+IR). All rats were provided with food and water ad libitum. The LD-AO+IR, MD-AO+IR and HD-AO+IR groups were given a daily dose of 2, 6 and 10 ml kg(-1)BW(-1) of AO, respectively, for 14 days prior to the IR operation. Tetrazolium chloride staining revealed that infarct size and the ratio of infarct weight to the total heart weight were decreased significantly in the three AO-treated groups compared to the IR group. The serum creatine kinase and aspartate aminotransferase activities also demonstrated similar beneficial effects. Myocardial catalase, superoxide dismutase, glutathione peroxidase, and constitutive nitric oxide synthase activities, as well as NO concentrations, were all increased, whereas malondialdehyde content and inducible nitric oxide synthase were decreased in AO-treated rats. These findings suggest that apricot kernel oil has potent cardioprotective effects, and could be developed as a nutriment for the treatment and prevention of myocardial infarcts.
本研究旨在评估杏仁油（AO）对体内大鼠心肌缺血再灌注（IR）的潜在心脏保护作用。将大鼠分为五组：假手术组、IR 组、低剂量 AO 处理的 IR 组（LD-AO+IR 组）、中剂量 AO 处理的 IR 组（MD-AO+IR 组）和高剂量 AO 处理的 IR 组（HD-AO+IR 组）。所有大鼠均自由进食和饮水。在 IR 手术前 14 天，LD-AO+IR、MD-AO+IR 和 HD-AO+IR 组分别给予 2、6 和 10mlkg(-1)BW(-1)的 AO 每日剂量。氯化四唑染色显示，与 IR 组相比，三种 AO 处理组的梗死面积和梗死重量与全心重的比值均显著降低。血清肌酸激酶和天冬氨酸转氨酶活性也表现出类似的有益作用。心肌过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶和结构型一氧化氮合酶活性以及 NO 浓度均升高，而 AO 处理组的丙二醛含量和诱导型一氧化氮合酶降低。这些发现表明杏仁油具有强大的心脏保护作用，可开发为治疗和预防心肌梗死的营养物质。
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