Department of Pharmacology, School of Pharmacy, Jilin University, Changchun, China.
Pharm Biol. 2011 Sep;49(9):900-6. doi: 10.3109/13880209.2011.554845. Epub 2011 May 19.
Panax ginseng C. A. Mey (Araliaceae) has been widely used in clinic for treatment of cardiovascular diseases in China. Ginsenoside Rb3 is the main chemical component of Panax ginseng.
The aim of this study was to evaluate the effect of ginsenoside Rb3 on myocardial ischemia-reperfusion injury in rats.
Sprague--Dawley rats were orally treated with Rb3 (5, 10 or 20 mg/kg) daily for 3 days followed by subjecting to left anterior descending coronary artery ligation for 30 min and reperfusion for 24 h.
This study showed that ginsenoside Rb3 treatment resulted in a reduction in myocardial infarct size. Ginsenoside Rb3 significantly attenuated the changes of creatine kinase activity and lactate dehydrogenase activity. The cardioprotective effect of ginsenoside Rb3 was further confirmed by histopathological examination. Ginsenoside Rb3 alleviated the increase of malondialdehyde content and the decrease of superoxide dismutase activity in left ventricle. Treatment with ginsenoside Rb3 also decreased plasma endothelin and angiotensin II levels.
These findings suggested that ginsenoside Rb3 possesses the effect against myocardial IR injury and the underlying mechanism is related to its antioxidant activity and microcirculatory improvement.
人参（五加科）在临床上被广泛用于治疗心血管疾病。人参皂苷 Rb3 是人参的主要化学成分。
本研究旨在评价人参皂苷 Rb3 对大鼠心肌缺血再灌注损伤的影响。
Sprague-Dawley 大鼠连续 3 天每天口服 Rb3（5、10 或 20mg/kg），然后结扎左前降支冠状动脉 30min 再灌注 24h。
本研究表明，人参皂苷 Rb3 治疗可减少心肌梗死面积。人参皂苷 Rb3 显著减轻肌酸激酶活性和乳酸脱氢酶活性的变化。人参皂苷 Rb3 的心脏保护作用通过组织病理学检查得到进一步证实。人参皂苷 Rb3 减轻了左心室丙二醛含量的增加和超氧化物歧化酶活性的降低。人参皂苷 Rb3 治疗还降低了血浆内皮素和血管紧张素 II 水平。
这些发现表明，人参皂苷 Rb3 具有抗心肌 IR 损伤的作用，其作用机制与其抗氧化活性和改善微循环有关。
