Braham Jmili Nejia, Sendi Halima, Khelif Abderrahim
Laboratoire d'hématologie, CHU Farhat Hached, Sousse, Tunisie.
Ann Biol Clin (Paris). 2011 Jul-Aug;69(4):473-5. doi: 10.1684/abc.2011.0595.
Acute lymphoblastic leukemia Type T PH1 positive (with t (9.22)) are exceptional. These effects can occur immediately or in the evolution of chronic myeloid leukemia known. We report the case of a patient aged 31 years with acute lymphoblastic leukemia T PH1 + cyologiques with cytological atypia. The overall appearance of blood and marrow: the signs of dysplasia the presence of a monocytic contingent, with blood monocytes evoked a myeloid acute leukemia AL. But the immunophenotype was unequivocally in favor of T- acute lymphoblastic leukemia with one aspect of lymphoid blasts in morphology and myeloperoxidase negative. The karyotype showed the presence of Philadelphia chromosome in all mitoses with additional abnormalities (chromosomes 2, 11.16…).
T型急性淋巴细胞白血病伴PH1阳性（t(9;22)）极为罕见。这些效应可立即出现，或在已知的慢性髓性白血病进展过程中出现。我们报告一例31岁患者，患有T型急性淋巴细胞白血病伴PH1阳性且有细胞异型性。血液和骨髓的整体表现：存在发育异常迹象、单核细胞群，血液中的单核细胞提示急性髓性白血病（AL）。但免疫表型明确支持T型急性淋巴细胞白血病，其淋巴母细胞在形态上有一个方面，且髓过氧化物酶阴性。核型显示在所有有丝分裂中均存在费城染色体，并伴有其他异常（2号、11号、16号染色体……）
