Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15118-22. doi: 10.1073/pnas.1113137108. Epub 2011 Sep 6.
Psychological resources--optimism, mastery, and self-esteem--buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.
心理资源——乐观、掌控感和自尊——可以缓冲压力的有害影响，是神经生理和心理健康相关结果的预测指标。这些资源具有高度的遗传性，但遗传基础尚不清楚。在这里，我们报告了催产素受体（OXTR）SNP rs53576 与心理资源之间的联系，即与 G/G 纯合子相比，“A”等位基因的携带者具有较低水平的乐观、掌控感和自尊。OXTR 也与抑郁症状有关。中介分析表明，OXTR 对抑郁症状的影响可能在很大程度上是由 OXTR 对心理资源的影响介导的。
