短篇报道：巴西有和无后天免疫机能丧失综合征人类感染马红球菌中与毒力相关的质粒鉴定。
Short report: Identification of virulence-associated plasmids in Rhodococcus equi in humans with and without acquired immunodeficiency syndrome in Brazil.
机构信息
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, Universidad Estadual Paulista, Botucatu, Sao Paulo, Brazil.
出版信息
Am J Trop Med Hyg. 2011 Sep;85(3):510-3. doi: 10.4269/ajtmh.2011.10-0695.
Abstract
Virulence of Rhodococcus equi strains from 20 humans in Brazil was investigated by using a polymerase chain reaction to characterize isolates as virulent (VapA), intermediately virulent (VapB), and avirulent. Nine isolates were obtained from human immunodeficiency virus (HIV)-positive patients, six from HIV-negative patients, and five from patients of unknown status. Five isolates were VapB positive, four were VapA positive, and eleven were avirulent. Among the nine isolates from HIV-positive patients, five contained VapB plasmids and two contained VapA plasmids. Five VapB-positive isolates had the type 8 virulence plasmid. Eleven of the patients had a history of contact with livestock and/or a farm environment, and none had contact with pigs.
摘要
对来自巴西的 20 位人类的马红球菌菌株的毒力进行了研究，方法是使用聚合酶链反应来鉴定为毒力（VapA）、中度毒力（VapB）和无毒力的分离株。从艾滋病毒（HIV）阳性患者中获得了 9 个分离株，从 HIV 阴性患者中获得了 6 个分离株，从患者未知状态中获得了 5 个分离株。5 个分离株为 VapB 阳性，4 个为 VapA 阳性，11 个为无毒力。在来自 HIV 阳性患者的 9 个分离株中，有 5 个含有 VapB 质粒，有 2 个含有 VapA 质粒。5 个 VapB 阳性分离株具有 8 型毒力质粒。11 位患者有与牲畜接触的病史和/或农场环境接触史，没有与猪接触。
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