达因素/ AIF-1对INS-1细胞中β细胞功能障碍的影响。
Effects of daintain/AIF-1 on β cell dysfunction in INS-1 cells.
作者信息
Huang Xinyuan, Zhao Yanying, Jia Shaohui, Yan Dongjing, Chen Zhengwang
机构信息
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, China.
出版信息
Biosci Biotechnol Biochem. 2011;75(9):1842-4. doi: 10.1271/bbb.110317. Epub 2011 Sep 7.
We investigated the effects of daintain/AIF-1, a novel inflammatory cytokine, on INS-1β cells. Cells incubated with daintain/AIF-1 showed decreased cell viability and glucose-stimulated insulin secretion, as well as upregulated apoptosis and NO production. These deleterious effects of daintain/AIF-1 indicate that daintain/AIF-1 plays important roles in the dysfunction of pancreatic β cells in type-1 diabetes.
我们研究了一种新型炎症细胞因子达因蛋白/铝激活蛋白-1（daintain/AIF-1）对INS-1β细胞的影响。用达因蛋白/铝激活蛋白-1孵育的细胞显示细胞活力降低、葡萄糖刺激的胰岛素分泌减少，以及细胞凋亡和一氧化氮（NO）生成上调。达因蛋白/铝激活蛋白-1的这些有害作用表明，达因蛋白/铝激活蛋白-1在1型糖尿病胰腺β细胞功能障碍中起重要作用。
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