米曲霉的laeA基因调控曲酸合成基因。
Aspergillus oryzae laeA regulates kojic acid synthesis genes.
作者信息
Oda Ken, Kobayashi Akiko, Ohashi Shinichi, Sano Motoaki
机构信息
Genome Biotechnology Laboratory, Kanazawa Institute of Technology.
出版信息
Biosci Biotechnol Biochem. 2011;75(9):1832-4. doi: 10.1271/bbb.110235. Epub 2011 Sep 7.
PMID:21897021
Abstract
Kojic acid synthesis genes regulation was investigated in Aspergillus oryzae. Our results indicate that kojic acid production was lost in the laeA disruption strain, but was recovered in the LaeA complement strain. Real-time PCR also confirmed that expression of kojic acid biosynthesis genes decreased in the laeA disruption strain, indicating that these genes are under the control of LaeA.
摘要
对米曲霉中曲酸合成基因的调控进行了研究。我们的结果表明，在laeA缺失菌株中曲酸产量丧失，但在LaeA互补菌株中得以恢复。实时PCR也证实，在laeA缺失菌株中曲酸生物合成基因的表达下降，这表明这些基因受LaeA调控。
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