Department of Pharmacy, Kyushu University Hospital, Higashi-ku, Fukuoka 812-8582, Japan.
J Pharmacol Sci. 2011;117(2):116-20. doi: 10.1254/jphs.11062sc. Epub 2011 Sep 7.
Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is delivered to tumors and increases antitumor activity compared with solvent-based paclitaxel. However, in a clinical trial, higher and lower rates of peripheral neuropathy and neutropenia were observed. In this study, we compared the effects of nab-paclitaxel and standard paclitaxel on pain behaviors in rats. Repeated administration of nab-paclitaxel dose-dependently induced both mechanical and cold allodynia, and the effects of nab-paclitaxel on pain behaviors tended to be stronger than that of standard paclitaxel at the doses used clinically. These results suggest that closer attention must be paid to the neuropathy when administering nab-paclitaxel in clinical settings.
纳米白蛋白结合紫杉醇（nab-紫杉醇）递送至肿瘤部位，与基于溶剂的紫杉醇相比，增加了抗肿瘤活性。然而，在一项临床试验中，观察到外周神经病变和中性粒细胞减少症的发生率更高和更低。在这项研究中，我们比较了 nab-紫杉醇和标准紫杉醇对大鼠疼痛行为的影响。重复给予 nab-紫杉醇剂量依赖性地诱导机械性和冷感觉异常，并且 nab-紫杉醇对疼痛行为的作用在临床使用的剂量下似乎比标准紫杉醇更强。这些结果表明，在临床环境中给予 nab-紫杉醇时，必须更加注意神经病变。
