Rajpurohit H, Sharma P, Sharma S, Purohit S, Bhandari A
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, India.
J Young Pharm. 2011 Jul;3(3):211-5. doi: 10.4103/0975-1483.83763.
In the present study, fast disintegrating tablets were designed with a view to enhance patient compliance. In this method, the hull of Hordeum vulgare, cross carmellose sodium, and sodium starch glycolate were used as superdisintegrants (4 and 6%), along with microcrystalline cellulose and mannitol, to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on the in vitro dispersion time, the formulations were tested for the in vitro drug release pattern. Tablets having H. vulgare hull showed the release profile comparable to those tablets having sodium starch glycolate and cross carmellose sodium.
在本研究中，设计速崩片是为了提高患者的顺应性。在该方法中，使用大麦外壳、交联羧甲基纤维素钠和羟丙基淀粉（用量为4%和6%）作为超级崩解剂，同时加入微晶纤维素和甘露醇以改善口感。对制备的片剂批次进行硬度、脆碎度、药物含量均匀度、湿润时间、吸水率和体外分散时间的评估。基于体外分散时间，对制剂进行体外药物释放模式测试。含有大麦外壳的片剂显示出与含有羟丙基淀粉和交联羧甲基纤维素钠的片剂相当的释放曲线。
