Chaluvaraju Kc, Bhat Ki
Department of Pharmaceutical Chemistry, Government College of Pharmacy, Bangalore, India.
J Young Pharm. 2011 Jul;3(3):243-5. doi: 10.4103/0975-1483.83775.
Studies were conducted on the anthelmintic property of about 15(e-h, 1e-1h, 2d-2f and 3e-3h) synthesized aminobenzylated Mannich bases bearing N-methyl piperazine using Indian earthworms Pheritima Posthuma against piperazine citrate as standard reference. Three concentrations of each compound (0.1, 0.2, 0.3% w/v) were studied, which involved the determination of paralysis and death time of the worms. The compound 1g exhibited the most significant anthelmintic activity among all the compounds screened against the worms as compared to standard drug.
使用印度蚯蚓正蚓（Pheritima Posthuma），以枸橼酸哌嗪作为标准对照，对约15种（e-h、1e-1h、2d-2f和3e-3h）合成的带有N-甲基哌嗪的氨基苄基化曼尼希碱的驱虫特性进行了研究。研究了每种化合物的三种浓度（0.1、0.2、0.3% w/v），其中包括测定蚯蚓的麻痹和死亡时间。与标准药物相比，在筛选的所有化合物中，化合物1g对蚯蚓表现出最显著的驱虫活性。
